Pdf epidemiology of opisthorchis viverrini melissa. Author summary opisthorchiasis, caused by an infection with the liver fluke, opisthorchis viverrini, is a neglected tropical disease endemic in southeast asia, particularly thailand and lao pdr. From the greek opisthen behind and orchis testicle, opisthorchis is a genus of trematode flatworms whose testes are located in the posterior end of the body. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Opisthorchis viverrini and opisthorchis felineus, also called the southeast asian liver fluke and cat liver fluke respectively, usually cause infections that. Proteins in the excretorysecretory products and tegumental surface membranes of the fluke have been proposed to play pivotal roles in parasite survival in the host, and subsequent pathogenesis.
Jul 18, 2018 388 in vitro diagnostic for the liver flukes opisthorchis viverrini and clonorchis sinensis. Opisthorchis viverrini is the biggest causative organism for this disease. Furthermore, liver fluke infection is associated with a high incidence of liver pathology including cholangiocarcinoma cca 3, 4. Opisthorchis viverrini an overview sciencedirect topics. Pdf opisthorchis viverrini liver fluke as the lot of baleful parasite. The opisthorchis viverrini genome provides insights into.
This article is from nature communications, volume 5. Due of the impact of control programs, the prevalence and worm. Opisthorchis viverrini is found mainly in northeast thailand, laos, cambodia, and central and southern vietnam. Opisthorchis viverrini infection and cholangiocarcinoma are serious problems in south east asia. Opisthorchis viverrini is a food borne trematode, important because of the sheer numbers of people infected and its serious morbidities such as hepatobiliary diseases and cholangiocarcinoma chca. Since that time, new data have become available, these have been incorporated in the monograph, and taken into consideration in the present evaluation. Research article a large scale study of the epidemiology and. Molecular changes in opisthorchis viverrini southeast asian liver. In lao pdr, detailed investigations on opisthorchis viverrini are scarce. The human liver fluke opisthorchis viverrini is endemic in different countries of southeast asia including thailand, lao pdr, cambodia, southern part of vietnam and myanmar 1, 2. These results indicate that t cell deprivation of the hamster host ameliorates the periductular inflammatory response provoked by o. From the greek opisthen behind and orchis testicle, opisthorchis is a genus of trematode flatworms. The species known as clonorchis sinensis has sometimes been reclassified into the genus opisthorchis. T cell deprivation appeared to have no effect on worm establishment or egg production.
Histopathologically, intact and deprived animals showed similar degrees of bile duct hyperplasia and periductular fibrosis, though there was a marked reduction in the intensity of the periportal. This species uses common cyprinoid fishes as second intermediate hosts as does opisthorchis viverrini, with which it is sympatric in this province. Vaccination of hamsters with opisthorchis viverrini. Liver fluke infection caused by opisthorchis viverrini is a major public. Improvement of pcr for detection of opisthorchis viverrini. Mar 20, 2019 opisthorchis viverrini infection, and particularly repeated infection, is the primary risk factor for cca in northeast thailand 6, 9,10,11,12. Opisthorchiasis is one of foodborne trematode infections with clonorchiasis, fascioliasis and paragonimiasis in the world health organizations list of neglected. Although data from cambodia, laos and vietnam are rare, data from thailand often show wideranging variability in epidemiological. Abstractopisthorchiasis is a neglected, tropical disease caused by the carcinogenic asian liver fluke.
Infection with opisthorchis viverrini ov is known to underlie the high risk of cca in northeast thailand iarc, 1994, but the correlation between risk and infection is far from perfect, at both individual and community levels sriamporn et al. In this study, we refer to the liver fluke from ducks as. Praziquantel is the only option for treatment of the liver fluke infection opisthorchis viverrini. Opisthorchis viverrini is a trematode parasite that attacks the area of the bile duct including intra and extra hepatic bile ducts. Fasttrack proposals will be accepted number of anticipated awards. Acta tropica opisthorchis viverrini and opisthorchiasis.
Wolfe, in the travel and tropical medicine manual fifth edition, 2017. The human liver fluke, opisthorchis viverrini, is designated as a group 1 carcinogen, and is the major risk factor for cholangiocarcinoma in endemic countries throughout southeast asia. Opisthorchis viverrini coexist for a pzq dosecomparison trial. The liver fluke opisthorchis viverrini infects 10 million people in southeast asia and causes cholangiocarcinoma cca. Opisthorchis viverrini, clonorchis sinensis, and cholangiocarcinoma. Rapid molecular detection of opisthorchis viverrini in human fecal samples by am j trop med hyg. Infection with the parasite is called opisthorchiasis.
Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Efficacy of praziquantel against schistosoma mekongi and. Oct 20, 2014 umesha kr, kumar s, parvathi a, et al. Gene discovery for the carcinogenic human liver fluke, opisthorchis viverrini. Jan 01, 2007 in lao pdr, detailed investigations on opisthorchis viverrini are scarce. The infection causes significant morbidity in terms of hepatobiliary diseases and cholangiocarcinoma. Summary opisthorchis viverrini infections were established in immunologically intact and t cell deprived hamsters. Stool examination is unlikely to result in a diagnosis in persons whose only exposure to opisthorchis took place more than 2530 years ago the life span of a liver fluke, as the liver fluke must be living. The eggs of opisthorchis are very similar to those of clonorchis, another liver fluke, but can be distinguished by microscopic features. Mcconnaughey, in reference module in biomedical sciences, 2014. Eh5 commented that the liver fluke infection in thailand was caused by o viverrini, not by o felineus5, and this was confirmed later in.
The adult flukes deposit fully developed eggs that are passed in the feces. The liver flukes opisthorchis viverrini and clonorchis sinensis chronically infect over 30 million people in southeastern asia, resulting in significant morbidity and a predispoisition to cholangiocarcinoma cca. Opisthorchis viverrini was first discovered in an indian fishing cat, prionailurus viverrinus poirier, 1886, with its scientific name incorporating the species name of that host animal. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Identification, recombinant protein production, and functional. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. More than 340 species of helminths infect humans, of which at least 25 cause serious and occasionally fatal outcomes 1.
Epidemiology of opisthorchis viverrini in a rural district of. In vitro diagnostic for the liver flukes opisthorchis. Opisthorchis, or cat liver fluke disease, indicates two distinct infections. Pdf epidemiology of opisthorchis viverrini paiboon. This can be compared with a conservative estimate of ten million people infected with the liver fluke opisthorchis viverrini in thailand and laos alone. Comparative proteomic analysis of juvenile and adult liver fluke, opisthorchis viverrini supatra boonmee, kanokwan imtawil, chaisiri wongkham, sopit wongkham pages 233238. Prevalence of opisthorchis viverrinilike fluke infection in ducks in. A study of tribendimidine effects in vitro and in vivo on the liver fluke. The carcinogenic liver fluke opisthorchis viverrini o.
Pdf opisthorchis viverrini and opisthorchis felineus researchgate. The world health organization who estimates that approximately five million people with hiv live in the asiapacific region. May 30, 2002 comparative proteomic analysis of juvenile and adult liver fluke, opisthorchis viverrini supatra boonmee, kanokwan imtawil, chaisiri wongkham, sopit wongkham pages 233238. Proteins in the excretorysecretory products and tegumental surface membranes of the fluke have been proposed to play pivotal roles in parasite survival in the. Clonorchis sinensis infection has been reported from many parts of east asia russia, japan, korea and china, whereas o. Liver flukes infect the liver, gallbladder, and bile duct in humans. Fluke secreted and tegumental proteins contribute to the generation of a. Serum antibody response to opisthorchis viverrini antigen. Repeated praziquantel treatment and opisthorchis viverrini. Studies on opisthorchis viverrini in thailand1, american journal of epidemiology, volume 62, issue 2, 1 september 1955, pages 81115. Rapid labelfree analysis of opisthorchis viverrini eggs in. Liver flukes are platyhelminth parasites of the class trematoda, and opisthorchis viverrini o viverrini is a member of the family opisthorchiidae. Wed like to understand how you use our websites in order to improve them. Liver fluke infection caused by opisthorchis viverrini induces several hepatobiliary conditions including advanced periductal fibrosis apf and cholangiocarcinoma cca, but 25% of the infected population develops apf and 1% develop cca.
Although treatment with praziquantel pzq effectively cures o. Efficacy and safety of tribendimidine versus praziquantel. Epidemiology and prevalence of clonorchis sinensis and opisthorchis viverrini infection in humans. Pdf infection with the carcinogenic human liver fluke.
Although infections are identified throughout southeast asia, the epicenter is northeast thailand, where high prevalence coexists with a high incidence of chca. Suppression of mrnas encoding cd63 family tetraspanins. It is suggested that such inflammatory responses are evoked by parasite antigens which gain access to portal tract and surrounding areas, and that such reactions are immunopathologi. Opisthorchis viverrini is an important foodborne trematode in southeast asia. The liver fluke opisthorchis viverrini is a major public health problem in southeast asia, particularly in thailand, laos. Epidemiology of opisthorchis viverrini in a rural district. Opisthorchiasis, clonorchiasis, opisthorchis felineus, opisthorchis viverrini, cat liverfluke disease, payard baimai nai tub footnote 1 footnote 2 characteristics. Gene discovery for the carcinogenic human liver fluke. Currently, only three of these helminths, schistosoma haematobium blood fluke, clonorchis sinensis chinese liver fluke and opisthorchis viverrini thai liver fluke, have been definitively linked to cancer table 1 2. High macrophage activities are associated with advanced. Epidemiology of opisthorchis viverrini sciencedirect.
The opisthorchis viverrini genome provides insights into life. Trematodes flukes opisthorchis viverrini southeast asian liver fluke and opisthorchis felineus cat liver fluke. Media in category opisthorchis viverrini the following 7 files are in this category, out of 7 total. After ingestion by a suitable snail first intermediate host, the eggs release miracidia, which undergo in the snail several developmental stages sporocysts, rediae. Infection with opisthorchis viverrini and its associated cholangiocarcinoma cca is an underestimated problem in the mekong region of southeast asia, despite the widespread use of praziquantel and health education measures for parasite control.
Opisthorchiasis and opisthorchisassociated cholangiocarcinoma in. Cdc opisthorchis resources for health professionals. O viverrini is highly prevalent in thailand and laos while c. The innate immune response is the first line of defence, and macrophages are critical regulators of fibrosis. Liver flukeassociated cca carries a poor prognosis, partly because it is often detected at a late and advanced stage. Nov 16, 2017 praziquantel is the only option for treatment of the liver fluke infection opisthorchis viverrini. Posterior probability pp support for each of these major clades was 1. The objective was to document epidemiological features of o. People are infected after eating raw or undercooked fish. Pdf opisthorchiasis caused by opisthorchis viverrini remains a major public. Our molecular resources now underpin profound explorations of opisthorchiasiscca and the design of new interventions. A new fecal dna extraction protocol for the detection of o.
Oct 17, 2008 infection with opisthorchis viverrini and its associated cholangiocarcinoma cca is an underestimated problem in the mekong region of southeast asia, despite the widespread use of praziquantel and health education measures for parasite control. Rapid labelfree analysis of opisthorchis viverrini eggs. A random sample was selected villages, 15 householdsvillage, all household members aged 6. Current control efforts rely on drug treatment and health education. This liver fluke is classified as a carcinogen due to its causal links with cholangiocarcinoma cca development. A random sample was selected villages, 15 householdsvillage, all household members aged 6 months.
Efficacy and safety of tribendimidine versus praziquantel against. The aim of this study was to improve the sensitivity of the pcrbased diagnosis of o. Opisthorchis viverrini infection is highly prevalent in northeast thailand. Pdf opisthorchis viverrini and opisthorchis felineus. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Pdf opisthorchis viverrini and opisthorchiasis banchob. Opisthorchis viverrini and clonorchis sinensis biological. Mthfr polymorphisms and opisthorchis viverrini infection. A cdna encoding a novel eggshell protein ovesp with highglycine 49. We aimed to assess the efficacy and safety of a single, oral dose of tribendimidine, compared with praziquantel administered in two doses, in participants with o viverrini infection.
The opisthorchis viverrini genome provides insights into life in the. Opisthorchis viverrini, common name southeast asian liver fluke, is a foodborne trematode parasite from the family opisthorchiidae that infects the bile duct. Serum antibody response to opisthorchis viverrini antigen as. Opisthorchis species are liver fluke parasites that humans can get by eating raw or undercooked fish, crabs, or crayfish from areas in asia and europe where the parasite is found, including thailand, laos, cambodia, vietnam, germany, italy, belarus, russia, kazakhstan, and ukraine. Analysis of interventions against the liver fluke, opisthorchis viverrini. Infection by opisthorchis viverrini and other liver flukes in asia affect the poor and poorest people. Although infections are identified throughout southeast asia, the epicenter is northeast thailand, where high prevalence coexists with a high. Opisthorchis viverrini pdf opisthorchis viverrini liver fluke as the lot of. Opisthorchis viverrini, a human liver fluke, is highly prevalent in southeast asia. Definitive diagnosis of infection is usually achieved parasitologically through the discovery of fluke eggs in feces.
Thewarach lahan, porntip pinlaort2, jason mulvennat3, banchob sripa2, manop sripa2, michael j smout3, robin b gasser4, paul j brindley5 and alex loukas3. Opisthorchis viverrini is the most common biliary liver fluke of humans and has the strongest association with cholangiocarcinoma box 20. An opisthorchiid liver fluke was recently reported from ducks anas platyrhynchos in binh dinh province of central vietnam, and referred to as opisthorchis viverrinilike. Opisthorchis viverrini and clonorchis sinensis were considered by a previous iarc working group in 1994 iarc, 1994. We adapt a populationbased model of opisthorchis viverrini transmission dynamics to determine the effectiveness of. Comparing the performance of urine and coproantigen. Although data from cambodia, laos and vietnam are rare, data from thailand often show wideranging variability in epidemiological parameters. Opisthorchis viverrini life cycle pixelmasterdesign. Molecular characterization of a tetraspanin from the human.
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